1. Ramalingam Boobalan and Rong-Jie Chein* “Oxathiaborolium-Catalyzed Enantioselective [4 + 2] Cycloaddition and Its Application in Lewis Acid Coordinated and Chiral Lewis Acid Catalyzed [4 + 2] Cycloaddition” Org. Lett. 2021, ASAP. (10.1021/acs.orglett.1c02345)ol1c02345_0010

  2. Ching-Pei Hsu, Yi-Hung Liu, Ramalingam Boobalan, Ya-Fan Lin, Rong-Jie Chein*, and Ching-Wen Chiu* “Chiral Tetra-Coordinate Aluminum Cation in Catalysis” Organometallics 2021, 40, 1244-1251. (10.1021/acs.organomet.1c00036)om1c00036_0008

  3. Ranuka T. Hewage, Rou-Jie Huang, Shu-Jung Lai, Ya-Chu Lien, Shao-Hsing Weng, Dehai Li, Yu-Ju Chen, Shih-Hsiung Wu, Rong-Jie Chein*, and Hsiao-Ching Lin* “An Enzyme-Mediated Aza-Michael Addition Is Involved in the Biosynthesis of an Imidazoyl Hybrid Product of Conidiogenone B” Org. Lett. 2021, 23, 1904-1909. (10.1021/acs.orglett.1c00330)Org. Lett. 2021, 23, 5, 1904–1909

  4. Jia-Tsrong Jan, Ting-Jen Rachel Cheng, Yu-Pu Juang, Hsiu-Hua Ma, Ying-Ta Wu, Wen-Bin Yang, Cheng-Wei Cheng, Xiaorui Chen, Ting-Hung Chou, Jiun-Jie Shie, Wei-Chieh Cheng, Rong-Jie Chein, Shi-Shan Mao, Pi-Hui Liang, Che Ma, Shang-Cheng Hung, and Chi-Huey Wong “Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection” PNAS 2021, 118, e2021579118. (10.1073/pnas.2021579118)no33

  5. Nai-Pin Lin and Rong-Jie Chein* “Total Synthesis and Absolute Structure of N55, a Positive Modulator of GLP-1 Signaling” Org. Biomol. Chem. 2020, 18, 8899-8907. (10.1039/D0OB01722A)no32

  6. Yu-Rong Chen, Annavareddi Naresh, Suhas-Yuen Liang, Chun-Hung Ling, Rong-Jie Chein*, and Hsiao-Ching Lin* “Discovery of a Dual Function Cytochrome P450 that Catalyzes Enyne Formation in Cyclohexanoid Terpenoid Biosynthesis” Angew. Chem. Int. Ed. 2020, 59, 13537-13541. (10.1002/anie.202004435)no31

  7. Kuan-Lin Chen, Chen-Yu Lai, Mau-Truc Pham, Rong-Jie Chein, Yi Tang, and Hsiao-Ching Lin* “Enzyme-Catalyzed Azepinoindole Formation in Clavine Alkaloid Biosynthesis” Org. Lett. 2020, 22, 3302-3306. (10.1021/acs.orglett.0c01132)ol0c01132_0007

  8. Chia-Yi Lin, Hsin-Yi Wu, Ting-Jen Rachel Cheng, Jyung-Hurng Liu, Rou-Jie Huang, Tzu-Hung Hsiao, Chia-Jen Wang, Pei-Fang Hung, Albert Lan, Szu-Hua Pan*, Rong-Jie Chein*, Chi-Huey Wong and Pan-Chyr Yang “Suppression of Drug-Resistant Non-Small-Cell Lung Cancer with Inhibitors Targeting Minichromosomal Maintenance Protein” J. Med. Chem. 202063, 3172-3187. (10.1021/acs.jmedchem.9b01783)jm9b01783_0012

  9. Ting-Hung Chou, Bo-Hung Yu, Rong-Jie Chein* “ZnI2/Zn(OTf)2–TsOH: A Versatile Combined-Acid System for Catalytic Intramolecular Hydrofunctionalization and Polyene Cyclization” Chem. Commun. 2019, 55, 13522-13525. (10.1039/C9CC07242J)c9cc07242j-f1_hi-res

  10. Ming-Shiu Lin, Tse-Ming Hong, Ting-Hung Chou, Shuenn-Chen Yang, Wei-Chia Chung, Chia-Wei Weng, Mei-Ling Tsai, Ting-Jen Rachel Cheng, Jeremy J W Chen, Te-Chang Lee, Chi-Huey Wong, Rong-Jie Chein*, Pan-Chyr Yang* “4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting thecolchicine site of β-tubulin” Eur. J. Med. Chem. 2019, 181, 111584. (10.1016/j.ejmech.2019.111584)1-s2.0-S0223523419307184-fx1_lrg

  11. Singam Naveen Kumar, Suhas Ravindra Bavikar, Chebolu Naga Sesha Sai Pavan Kumar, Isaac Furay Yu, Rong-Jie Chein* “From Carbamate to Chalcone: Consecutive Anionic Fries Rearrangement, Anionic Si→C Alkyl Rearrangement and Claisen-Schmidt Condensation” Org. Lett. 2018, 20(17), pp5362-5366. (10.1021/acs.orglett.8b02269) Highlighted by Synfacts 2018, 14(11), 1180. (10.1055/s-0037-1611034)ol-2018-02269n_0008

  12. Hao-Wei Cheng, Rong-Jie Chein, Ting-Jen Cheng, Pei-Shan Wu, Hsin-Yi Wu, Pei-Fang Hung, Chia-Jen Wang, Yuan-Ling Hsu, Jau-Min Wong, Ang Yuan, Chi-Huey Wong, Pan-Chyr Yang, Szu-Hua Pan* “2-anilino-4-amino-5-aroylthiazole-type compound AS7128 inhibits lung cancer growth through decreased iASPP and p53 interaction” Cancer Sci. 2018, 109(3), 832-842. (10.1111/cas.13489)no25

  13. Singam Naveen Kumar, Isaac Furay Yu, Rong-Jie Chein* “Oxathiaborolium: a Type of Chiral Lewis Acid Catalyst and Its Application in Catalytic and Highly Enantioselective Diels−Alder Reactions” Org. Lett. 201719(1), 22-25. (10.1021/acs.orglett.6b03147). Highlighted by C&EN 2017.ol-2016-03147x_0006

  14. Shih-Che Lin, Rong-Jie Chein* “Total Synthesis of the Labdane Diterpenes Galanal A and Galanal B from Geraniol”  J. Org. Chem. 201782(3), 1575–1583. (10.1021/acs.joc.6b02766)jo-2016-027669_0010

  15. Shang-Hua Wang, and Rong-Jie Chein* “(Thiolan-2-yl)diphenylmethyl Benzyl Ether/N,N’-diarylurea Cocatalyzed Asymmetric Aziridination of Cinnamyl Bromide and Aryl Aldimine” Tetrahedron 2016, 72, 2607-2615. (10.1016/j.tet.2014.12.063)no22

  16. Chia-I Yen, Szu-Mam Liu, Wei-Shang Lo, Jhe-Wei Wu, Yi-Hsin Liu, Rong-Jie Chein, Renqiang Yang, Kevin C.-W. Wu, Jih Ru Hwu, Nianhan Ma,* Fa-Kuen Shieh* “Cytotoxicityof Postmodified Zeolitic-Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity” Chem. Eur. J. 2016, 22, 2925-2929. (10.1002/chem.201505005)no21

  17. Klim King*, Nai-Pin Lin, Yu-Hong Cheng, Gao-Hui Chen, Rong-Jie Chein* “Isolation of Positive Modulator of Glucagon-like Peptide-1 Signaling from Trigonella foenum-graecum (Fenugreek) Seed” J. Biol. Chem. 2015290, 26235-26248. (10.1074/jbc.M115.672097)no20

  18. Darong Wang, Meiman Chen, Rong-Jie Chein, Wei-Min Ching, Chen-Hsiung Hung, Der-Lii M. Tzou* “Cation ion specifically induces a conformational change in trans-dehydroandrosterone – A solid-state NMR study” Steroids 2015, 96, 73-80. (10.1016/j.steroids.2015.01.011)no19

  19. Chin-Yin Lin, Rong-Jie Chein* “Lithiation of a Silyl Ether: Anionic Si→C Alkyl Migration” Synlett 2014, 25, 2827–2830. (10.1055/s-0034-1379493)Alkyl migration

  20. Hong-Jay Lo, Chin-Yin Lin, Mei-Chun Tseng, and Rong-Jie Chein* “Lithiation of a Silyl Ether; Formation on an ortho-Fries Hydroxyketone” Angew. Chem. Int. Ed. 2014, 53, 9026 –9029. (10.1002/anie.201404495)

  21. Chebolu Naga Sesha Sai Pavan Kumar, Rong-Jie Chein* “Synthesis of Labdane Diterpenes Galanal A and B from (+)–Sclareolide” Org. Lett. 2014, 16, 2990−2992. (10.1021/ol501121v)ol-2014-01121v_0009

  22. Meng-Ting Huang, Hsin-Yi Wu, Rong-Jie Chein* “Enantioselective Synthesis of Diaryl Aziridines Using Tetrahydrothiophene-Based Chiral Sulfides as Organocatalysts” Chem. Commun. 2014, 50, 1101-1103. (10.1039/C3CC47550F)no15

  23. Ravi Kumara Guralamatta Siddappa, Chih-Wei Chang, Rong-Jie Chein “From Precursor to Catalyst: The Involvement of [Ru(ƞ5-Cp*)Cl2]2 in Highly Branch Selective Allylic Etherfication of Cinnamyl Chloride” Tetrahedron Lett. 2014, 55, 1031-1035. (10.1016/j.tetlet.2013.12.074)organometallic catalysis

  24. Hsin-Yi Wu, Chih-Wei Chang, Rong-Jie Chein* “Enantioselective Synthesis of (Thiolan-2-yl)diphenylmethanol and Its Application in Asymmetric, Catalytic Sulfur Ylide-Mediated Epoxidation” J. Org. Chem. 2013, 78, 5788-5793. (10.1021/jo400648f)jo-2013-00648f_0006

  25. Chih-Wei Chang, Rong-Jie Chein* “The Absolute Configuration of Anti-HIV-1 Agent (-)-Concentricolide : Total Synthesis of (+)-(R)-Concentricolide” J. Org. Chem. 2011, 76, 4154-4157. (10.1021/jo2004132)jo-2011-004132_0004

  26. Rong-Jie Chein, E. J. Corey* “Strong Conformational Preferences of Heteroaromatic Ethers and Electron Pair Repulsion” Org. Lett. 2010, 12, 132-135. (10.1021/ol9025364)ol-2009-025364_0014

  27. Rong-Jie Chein, Ying-Yeung Yeung and E. J. Corey* “Highly Enantioselective Oxazaborolidine-Catalyzed Reduction of 1,3-Dicarbonyl Compounds: Role of the Additive Diethylaniline” Organic Letters 200911, 1611-1614. (10.1021/ol900258f)untitled

  28. László Kürti, Rong-Jie Chein and E. J. Corey* “Conformational Energetics of Cationic Backbone Rearrangements in Triterpenoid Biosynthesis Provide an Insight into Enzymatic Control of Product” J. Am. Chem. Soc. 2008130, 9031-9036. (10.1021/ja800980h)untitled

  29. Ying-Yeung Yeung, Rong-Jie Chein, and E. J. Corey* “Conversion of Torgov’s Synthesis of Estrone into a Highly Enantioselective and Efficient Process” J. Am. Chem. Soc. 2007129, 10346-10347. (10.1021/ja0742434)untitled

  30. Tse-Lok Ho, Rong-Jie Chein “Ritter Reaction of 1-Aryl-1-fluoro-2-haloethanes” J. Chin. Chem. Soc. 200653, 429-430. (10.1002/jccs.200600054)

  31. Tse-Lok Ho, Rong-Jie Chein “Total Synthesis of (+)-β-Himachalene” Helv. Chim. Acta. 2006, 89, 231-239. (10.1002/hlca.200690025)

  32. Tse-Lok Ho, Rong-Jie Chein “Unusual Thionation via Fragmentation” J. Chin. Chem. Soc. 200552, 1223-1225. (10.1002/jccs.200500176)

  33. Tse-Lok Ho, Rong-Jie Chein “Intervention of Phenonium Ion in Ritter Reactions” J. Org. Chem. 200469, 591-592. (10.1021/jo035561y)

  34. Tse-Lok Ho*, Liang-Ren Kung, and Rong-Jie Chein “Total Synthesis of (±)-2-Isocyanoallopupukeanane” J. Org. Chem. 200065, 5774-5779. (10.1021/jo000668w)

  35. Tse-Lok Ho*, and Rong-Jie Chein “A Synthesis of 6-Myoporol” J. Nat. Prod. 199760, 493-494. (10.1021/np960704f)

  36. Tse-Lok Ho, Rong-Jie Chein “Synthesis of (-)-Furodysinin from (+)-Limonene” Chem. Commun. 1996, 1147. (10.1039/CC9960001147)


  1. US patent US 10,392,357 B2 “Glucagon-like peptide 1 modulator and uses thereof”

  2. R.O.C. I516474「良薑化合物及其類似物之合成」

  3. US patent US 9,193,665 B2 “Synthesis of Galanal Compounds and Analogues thereof”